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[ESC2009]CURRENT OASIS 7研究解读:Shamir Mehta教授专访
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 编辑:国际循环网 时间:2009/9/1 11:56:00    加入收藏
 关键字:Shamir Mehta CURRENT OASIS 7研究 ACS 阿司匹林 


International Circulation:  Do gastrointestinal side effects trouble the choice of optimal dose of aspirin in the results of CURRENT OASIS 7?

《国际循环》:在CURRENT OASIS 7研究结果中,胃肠道不良反应是否困扰了阿司匹林最佳剂量的选择?

International Circulation:  As for gastrointestinal (GI) side-effects, there were 17 more GI bleeds in the high-dose aspirin arm compared to the low-dose aspirin arm.  It did not quite reach statistical significance.  When we consider that there were 25,000 patients in this trial, a 17 patient excess is incredibly small. On the other hand, the double dose clopidogrel and high-dose aspirin combination seemed to result in the lowest event rates.  Therefore, one could consider high-dose aspirin for a month and the double dose clopidogrel for a week.  It seems to be a safe and effective combination.  After one month the low-dose aspirin can be reinstituted and after one week the standard dose clopidogrel (75 mg) can be used.

S R Mehta教授:在胃肠道不良反应上,与小剂量阿司匹林组相比,大剂量阿司匹林组胃肠道出血多了17例。这并未完全达到统计学显著性。当我们考虑到在这一研究中共有25 000例患者,这17例的增多是非常小的数字。另一方面,氯吡格雷双倍剂量联合大剂量阿司匹林似乎事件发生率最低。因此,可以考虑大剂量阿司匹林应用1月且氯吡格雷双倍计量应用1周。 这看似一种安全有效的联合。1个月后则重新应用小剂量阿司匹林,以及1周后应用标准剂量的氯吡格雷(75 mg/d)。



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